At baseline, three pro-inflammatory markers’ levels were positively associated with overall depression severity (PHQ total score) and the somatic subscale score: TNFa (r = 0.275, p = 0.007 and r = 0.354, p = 0.001 respectively), Mip1b (r = 0.250, p = 0.014 and r = 0.288, p = 0.011) and sICAM1 (r = 0.276, p = 0.007 and r = 0.268, p = 0.018). The gene discussed is CCL4; the disease is major depressive disorder.