NFE2L2 and skin neoplasm: Later, in a murine skin cancer model that employed a single dose of DMBA followed by repeated applications over a 25-week period of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), Nrf2-ko mice developed more tumours than their wildtype counterparts and continuous topical application of SFN that was started prior to DMBA treatment did not diminish tumour numbers, whilst in wildtype mice SFN treatment decreased the incidence of tumours and the numbers per mouse over the duration of the experiment [92].