Molecular profiling of both LUAD and LUSC revealed thirty-eight genes frequently mutated in LUAD and twenty frequently mutated genes in LUSC, with six commonly mutated genes in both lung cancer subtypes: these are, TP53, RB1, ARID1A, CDKN2A, PIK3CA and NF1 [153] (see Table 3 for the frequency of mutations in genes implicated in NRF2 activation in NSCLC). This evidence concerns the gene NFE2L2 and lung carcinoma.