Furthermore, a curcumin-related compound called bis[2-hydroxybenzylidene]acetone (BHBA) has been shown to protect female A/J mice against the formation of lung adenocarcinoma when given for two weeks prior to the administration of vinyl carbamate, but even though BHBA was shown to induce ARE-driven luciferase activity, it remains uncertain whether in this instance chemoprevention is mediated by Nrf2 [102]. The gene discussed is NFE2L2; the disease is lung adenocarcinoma.