NFE2L2 and liver cancer: Following the discovery that NRF2 regulates both the basal and inducible expression of genes encoding drug-metabolising enzymes capable of detoxifying carcinogenic xenobiotics, various research groups investigated whether loss of the CNC-bZIP transcription factor might sensitise mice to tumourigenesis and diminish the effectiveness of chemopreventive agents in gastric, bladder, skin, gastrointestinal tract, oral, mammary, lung and liver cancer.