NFE2L2 and cancer: Besides directing the expression of genes encoding enzymes that scavenge ROS, NRF2 also controls the expression of PPP genes in both the oxidative (G6PD and PGD) and non-oxidative (TALDO1 and TKT) arms, and overexpression of these may contribute to survival and proliferation of cancer cells by increasing synthesis of NADPH and ribonucleotides [198].