NFE2L2 and cancer: Intriguingly, inhibition of autophagy, by chloroquine treatment or knockout of ATG7, in autophagy-dependent cancer cells stimulates adaptation by NRF2-mediated induction of proteasomal subunit genes, with largest increases observed for PSMB8, PSMB9, PSMB10 and PSMC1, indicating NRF2-mediated regulatory crosstalk between the proteasome and autophagy [36].