In terms of suppressing the GSH-based antioxidant system, inhibition of the GCLC/GCLM heterodimeric enzyme by buthionine sulfoximine, inhibition of GSR1 by 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoyl-sulfanyl]propionic acid (2-AAPA), and inhibition of the SLC7A11 antiporter by sulfasalazine or erastin, have been proposed as means of sensitizing tumour cells to chemo- and radiotherapy [282]. This evidence concerns the gene SLC7A11 and neoplasm.