NQO1 and cancer: However, Paul Talalay and colleagues pointed out that whilst the anti-cancer compounds that induce Nqo1 in murine Hepa1c1c7 cells varied enormously in structure, they were all Michael reaction acceptors and thus electrophilic in nature, and proposed that this was the trigger for induction of Nqo1, rather than some receptor-defined stereochemical property [111,112].