Shortly thereafter, it was discovered that somatic mutations in NFE2L2 commonly occur in NSCLC and oral cancer cell lines as well as various primary lung cancers and primary head and neck cancers, and that the somatic mutations resulted in amino acid substitutions at residues associated with the DLG and ETGE motifs in NRF2 [152]. This evidence concerns the gene NFE2L2 and lip and oral cavity carcinoma.