Examination of second-generation sequencing of a large number of tumours deposited in the catalogue of somatic mutations in cancer (COSMIC) and the cancer genome atlas (TCGA) databases revealed that NFE2L2 and KEAP1 are mutated in various common cancers, including lung, head and neck, and bladder [153,154,155,156,157,158,159] (see Table 2). Here, KEAP1 is linked to cancer.