SLC7A11 and pancreatic ductal adenocarcinoma: An example of this approach is the tamoxifen-induced conditional knockout of Slc7a11 in pancreatic ductal adenocarcinoma cells generated in KrasLSL-G12D/+; Tp53R172H/+; Pdx1FlpOtg/+; Slc7a11Fl/Fl; Rosa26CreERT2/+ mice, experiments in which knockout of Slc7a11 in the tumour resulted in ferroptotic death of the tumour cells and increased survival [199].