KRAS and pancreatic neoplasm: Research into the inhibitory effects of oxidative stress on tumourigenesis in a murine Kras oncogenic pancreatic cancer model has revealed that Nrf2 is necessary for Kras-driven pre-invasive pancreatic intraepithelial neoplasia as the number of lesions in KrasLSL-G12D/+; Nfe2l2−/− mice was much lower than in KrasLSL-G12D/+; Nfe2l2+/+ mice [164].