NFE2L2 and cancer: In a mouse model in which a constitutively active form of Nrf2 that lacks amino acids 1–88 (i.e., Nrf2ΔNeh2, called caNrf2) was expressed from the keratin 5 promoter (with the line called K5cre-caNrf2), the mutant mice developed chloracne-like skin disease with hyperkeratosis of hair follicles in the epidermis [186], but not cancer.