SHMT2 and cancer: Moreover, as NRF2 regulates ATF4, it indirectly controls serine synthesis by regulating expression of genes encoding phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase-1 (PSAT1) and serine hydroxymethyltransferase-2 (SHMT2), and as serine is used as an intermediate in glutathione and nucleotide production, NRF2 upregulation supports cancer cell growth and proliferation [204].