NFE2L2 and neoplasm: Support for the notion that Nrf2 differentially influences the various stages of carcinogenesis has come from the fact genetic activation of Nrf2, using the Keap1-floxed hypomorph (i.e., Keap1-knockdown or Keap1FA/FA) mouse, protects mice against tumourigenesis, probably by upregulating genes encoding enzymes that detoxify the ultimate carcinogen vinyl carbamate epoxide, but that the tumours obtained from the Keap1FA/FA mice grew more robustly when transplanted into nude mice than those from Keap1+/+ mice [105].