NFE2L2 and neoplasm: When comparing the impact of mutations in NFE2L2 or KEAP1 on expression of NRF2-target genes, mutations in NFE2L2 were found to result in overexpression of more genes compared to mutations in KEAP1, suggesting that amino acid substitutions within the transcription factor are a more robust way for the tumour to command a comprehensive oxidative stress response [218].