Furthermore, persistent hyperactivation of NRF2 in human A549 lung cancer cells results in enhancer remodelling, allowing transcriptional activation of NOTCH3 by an NRF2-CEBPB complex that strongly supports tumourigenesis, and which is not observed in normal cells under stress conditions, indicating that continual activation of NRF2 in cancer cells results in overexpression of an enlarged battery of genes that is distinct from that induced by NRF2 in normal cells [183]. Here, NFE2L2 is linked to lung carcinoma.