A similar observation was reported in a sepsis model of HF in mice, in which in vivo treatment with a β3-AR agonist (CL316243) exacerbated cardiac dysfunction, while a β3-AR antagonist (SR59230A i.p. injections) prevented cardiac dysfunction in parallel with decreased iNOS expression and left ventricular NO concentration [41]. The gene discussed is ADRB3; the disease is Sepsis.