NOS1 and heart disorder: Given the cooperative effects of eNOS and nNOS on cardiomyocyte contractility in cardiac diseases (reviewed in Farah et al. [32]), and the previous observation that nNOS translocates from the sarcoplasmic reticulum to the plasma membrane in failing human hearts [55], the antioxidant effect mediated by the nNOS-eNOS crosstalk and subsequently preserved NOS/sGC/cGMP signaling would reinforce the cardioprotective effect of β3-AR stimulation in the failing myocardium.