IL1B and Gingival bleeding: Several studies have proven the effectiveness of laser use during periodontal therapy, highlighting an improvement in depth of survey, in the gain of clinical attachment and in the reduction of gingival bleeding in moderate and severe pockets: after a single application of the 810 nm diode laser, improvements have been achieved in parameters such as PPD and CAL [56,73,100] but also in levels of IL1-β [62]; other authors, however, argue that there are no further benefits in clinical parameters with the use of a diode laser, compared to/e solo/e scaling and root planning [101].