CD274 and neoplasm: The “hot” cluster, enriched in LUSC lesions, (while LUADs were similarly distributed in the hot and in the cold clusters), was characterized by strong signals for CD8+ T cells, high expression of inhibitory receptors PD-1 and TIM-3 on CD8+ T cells, FOXP3+ Treg infiltration and expression of PD-L1 on tumor and immune cells.