Collectively, these results indicated that the tumor microenvironment of early LUAD shows profound alterations of several immune compartments, including enrichment for PPARγhiCD64hiCD14hiIL-6hi macrophages, CD1c+ DC, Tregs, and exhausted T cells and depletion of CD141+ DCs, CD16+ monocytes, NK cells, and granzyme B+ effector cells. This evidence concerns the gene GZMB and neoplasm.