TNF and neoplasm: Therefore, for a more efficient antitumor response, the changing tumor microenvironment increasing the degree of activation of the antitumor immune system will probably be necessary, which could be achieved through the stimulation of CTLs and NK cells, stimulated with cytokines such as IL-2, IFN-γ, TNF-α, and IL-12, plus the presentation of extracorporeal antigen [10].