The results of the survival analysis in phase III PALOMA-3 trial for HR-positive, HER-2 negative advanced BC showed that treatment with palbociclib–fulvestrant resulted in longer OS than treatment with placebo–fulvestrant (34.9 months, 95% CI: 28.8 to 40.0 vs. 28.0 months, 95% CI: 23.6 to 34.6; HR: 0.81; 95% CI, 0.64 to 1.03; p = 0.09) [41]. The gene discussed is ERBB2; the disease is breast cancer.