Recently, in phase I/II open-label trial of with nivolumab (anti-PD-1mAb) plus ipilimumab (anti-CTLA-4-mAb) in TNBC (NCT01928394), and in a single-arm phase II trial of durvalumab plus tremelimumab (anti-CTLA-4-mAb) for HER-2 negative MBC (NCT02536794), the results suggest improved clinical responses by checkpoint blockade therapy due to their high immunogenicity observed in these cancer types. The gene discussed is CTLA4; the disease is cancer.