One interesting approach can be the co-activation of macrophages (MΦs) (retinoic acid), NK cells (IL-15, IL-22, and IL-23), cytotoxic T cells (CTLs) (IL-2, TNF-α, IFN-γ), and the acquisition and presentation of tumor antigens by dendritic cells [152]. The gene discussed is IL2; the disease is neoplasm.