Other cytokines/chemokines that play a role in the inflammatory response have been associated with prognosis in adult HL as well, including elevated IL-6, IL-10, TNF receptor, sGal-1, and tumor necrosis factor receptor superfamily member 8 (or sCD30) [22,25,32,33]. This evidence concerns the gene TNFRSF8 and Hodgkins lymphoma.