Inflammatory mediators, including C-C motif chemokine 17 (CCL17, also known as thymus and activation regulated chemokine (TARC)), soluble CD163 (sCD163), tumor necrosis factor receptor superfamily member 8 (also known as soluble CD30 (sCD30)), interleukin-6 (IL-6), soluble IL-2 receptor alpha (IL-2Rα, also known as sCD25) and soluble Galectin-1 (sGal-1), are prognostic in adult HL [2,3,4,5,6,7]. The gene discussed is TNFRSF8; the disease is Hodgkins lymphoma.