While the prognostic significance of macrophages in HL is conflicting [2,25,36,37,38,39], certain proteins secreted by macrophages were associated with HL vs. controls (e.g., growth-regulated alpha protein, TGF-α, and CXCL10) or were related to clinical outcomes (e.g., IL-8) in our study (Table S4). The gene discussed is CXCL10; the disease is Hodgkins lymphoma.