TENM4 and ventricular septal defect: The genes with SVs in Twin2_TOF, encoding for Bardet-Biedl Syndrome 2 (BBS2) and Teneurin Transmembrane Protein 4 (TENM4), are also associated with differential DNA methylation in VSD cases versus normal hearts (i.e., significantly hypermethylated gene body of BBS2 and hypermethylated promoter of TENM4) [10].