Specifically, treatment of pancreatic cancer with doxorubicin, paclitaxel or 4-hydroxy-cyclophosphamide (4H-CPA) chemotherapies resulted in CAF-induced STAT-1 and NF-κB activity leading to the secretion of ELR motif-positive (ELR+) chemokines. Here, STAT1 is linked to familial pancreatic carcinoma.