Considering PIPP, SHIP2 and SYNJ2 also dephosphorylate PtdIns(4,5)P2, the role of the 5-phosphatases in regulating PtdIns(4,5)P2-effector interactions in breast cancer cells should be considered as another mechanism by which these enzymes may differentially regulate cell migration and invasion. The gene discussed is INPPL1; the disease is breast cancer.