Pten knock-in (KI) mice harbouring cancer-associated and loss-of-function Pten mutations such as the PtenC124S/+ or the PtenG129E/+ mutation, are highly tumour prone and develop tumours in multiple tissues including in the thyroid, adrenal gland, gallbladder, prostate and mammary gland, similar to Pten+/− mice [42]. Here, PTEN is linked to cancer.