In addition to genomic loss, PTEN missense and nonsense mutations occur in 5.49% of breast cancers, whereas mutations in the 5-phosphatases are less common: PIPP 0.62%, SHIP2 1.79% and SYNJ2 3.6% of breast cancers (COSMIC database, cancer.sanger.ac.uk) [143]. Here, PTEN is linked to breast cancer.