SHIP2 interacts with various cancer related proteins such as c-cbl [131], p130Cas [87], filamin [86], vinexin [132], c-met [133], EphA2 receptor [134], RhoA [135] and c-Jun N-terminal kinase 1 (JNK)-interacting protein (JIP1) [136] by its N-terminal SH2 domain, C-terminal proline rich domain and unique SAM domain [129]. This evidence concerns the gene INPPL1 and cancer.