MAPT and Alzheimer disease: For example, in AD brains, α-synuclein has been reported to coexist with amyloid-β in senile plaques and in degenerating neuritis [110], and glial tau, neuronal tau and TDP-43 pathology, predominant pathology associated with FTD, limbic-predominant age-related TDP-43 encephalopathy (LATE) dementia and ALS, can also be present in AD and parkinsonian plus syndromes [3,111].