Work is ongoing to investigate the role of SV2A in ALS, using (11C)UCB-J PET as part of the MIND-MAPS program (https://lp.invicro.com/mind-maps), which could help to provide a comprehensive understanding of the role of SV2A across the spectrum of age-related neurodegenerative diseases. This evidence concerns the gene SV2A and amyotrophic lateral sclerosis.