Recent studies on tumor vascular ECs (referred as TVECs) purified from CRC tissues using iTRAQ-based quantitative proteomics analysis, among several groups of differentially expressed proteins (DEPs) and signaling pathways, also indicated proteins important in angiogenesis (e.g., HIF1 and PI3K/Akt signaling pathway-related proteins) were upregulated in TVECs compared with the controls [131]. This evidence concerns the gene HIF1A and neoplasm.