In CRC progression and angiogenesis, simultaneous hyperactivation of Wnt/β-catenin signaling and inhibition of the phosphatidylinositol 3’ kinase (PI3K)/Akt pathway promote nuclear accumulation of β-catenin and the Forkhead box 03 protein (FOXO3a), respectively, promoting metastasis by regulating a panel of target genes [2]. Here, AKT1 is linked to colorectal carcinoma.