An interesting model of the regulating influence of Wnt signaling on cancer metabolism and angiogenesis through pyruvate dehydrogenase kinase 1 (PDK1), as a direct Wnt target gene, was demonstrated by Pate et al. They reported that Wnt/β-catenin signaling directs a metabolic program of glycolysis in colon cancer cells (as a common cancer phenotype called the Warburg effect) and affects the tumor microenvironment through increased vessel development [66]. Here, PDK1 is linked to malignant colon neoplasm.