Other HIF-1 target genes with proven roles in colon carcinoma cell invasion include vimentin, keratins 14, -18, -19, fibronectin 1, matrix metalloproteinase 2 (MMP-2), urokinase-type plasminogen activator receptor (uPAR), cathepsin D, and autocrine motility factor (AMF) [58]. The gene discussed is GPI; the disease is colon carcinoma.