When it comes to the role of serum concentration of Wnt signaling components, as markers of CRC angiogenesis, it was proven that serum VE-cadherin was about fourfold higher in CRC patients compared with the controls, but it was not correlated with the VEGF level and any clinicopathological data (sex, age, tumor site, lymph node metastasis, grade, the subtype of CRC). This evidence concerns the gene CDH5 and neoplasm.