CBL and colorectal carcinoma: Similarly, in the case of the Casitas B-lineage lymphoma (c-Cbl) gene encoding CBL protein, which plays a role as an E3 ubiquitin-protein ligase, it was proven that mutant C-Cbl-Y371H resulted in augmented Wnt/β-catenin signaling, increasing Wnt gene expression, angiogenesis, and CRC growth.