Similarly, in patients with Parkinson’s disease (PD), accumulations of α-synuclein and Lewy body pathology in the substantia nigra pars compacta neurons may in part be a result of elevated SASP-induced cytokines, such as IL-1β, IL-6, and TNFα, generated by senescent astrocytes and other cells [90]. The gene discussed is TNF; the disease is Parkinson disease.