The enhancement of Nrf2 pathway, and the subsequent increase of HO-1 levels and the inhibition of Nf-κB activation are effects observed in several pre-clinical models of IBD after the administration of others herbal-derivate compounds such as Genipin [154], Toosendanin [155], or A.japonica extracted ethanol [156]. This evidence concerns the gene HMOX1 and inflammatory bowel disease.