For instance, in colorectal cancer, some studies highlight a better long-term survival and less metastases when HO-1 is expressed, and lower HO-1 expression at high grade stages [166]; meanwhile other studies observed that the high HO-1 expression in colorectal cancer cells is linked to tumor progression and metastasis, by inhibiting apoptosis and promoting angiogenesis and immunological scape [167]. This evidence concerns the gene HMOX1 and colorectal cancer.