UBB and amyotrophic lateral sclerosis: Of note, the NeuroArray-based genomic signature of the ALS proband was reproduced by functional enrichment analysis of WES data generated for this patient, further supporting the role of cytoskeletal defects in axons and aberrant transmembrane transport, as well as immune response and regulation of ubiquitin-mediated proteolysis in disease pathogenesis (Figure 2 and Supplementary Materials Table S7).