Among these, we distinguished SNV and indel variations in some SCA genes (ATXN3, ATXN7, and ATXN2L), as well as known ALS-linked genes (i.e., SETX and VCP), suggesting that genetic variations in these genes may play an additive role in potentiating the neuropathological effects mediated by ATXN1 repeat expansion (Figure 3b and Supplementary Materials Table S6). The gene discussed is ATXN2L; the disease is autosomal dominant cerebellar ataxia.