In that study, doxorubicin treated animals were found to exhibit elevated levels of cardiac injury markers such as lactate dehydrogenase (LDH), creatine phosphokinase (CPK), serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) and exhibited arrhythmia when examined using electrocardiogram (ECG). This evidence concerns the gene PIK3C2A and cardiac arrhythmia.