Constitutive activation of PIP5K1α/PI3K/Akt pathways are involved in progression and poor response to androgen deprivation therapy in PCa [21, 36], we therefore examined effect of 17β‐Estradiol treatment on expression of PIP5K1α and phosphorylated Ser‐473 AKT. This evidence concerns the gene AKT1 and posterior cortical atrophy.