As reported in our previous studies, we found that clinically relevant gene profiles that are associated with PIP5K1α/AKT in subgroups of patients, and that elevated level of PIP5K1α was associated with poorer patient outcome [16] We therefore examined expression profiles of the target genes of tamoxifen identified by RNA‐seq as mentioned above by using primary tumors from PCa patients. This evidence concerns the gene AKT1 and posterior cortical atrophy.