Our research group has demonstrated the therapeutic effect of different human proteins like urokinase Plasminogen Activator (uPA) [11, 12], ΔTGFbRII [13] (TGFβ1 truncated receptor) and MMP8 [10, 14, 15] coded by cognate cDNAs resulting in significantly reduced fibrotic tissue in experimental cirrhosis models. Here, PLAU is linked to Cirrhosis.