The mRNA levels of tumor necrosis factor α (TNFα) and interleukin 6 (IL6) were increased in APL-KO mice compared with WT mice after MI operation, whereas no differences were observed in TNFα and IL6 expression between WT and APL-KO mice after sham operation (Fig 2A). The gene discussed is TNF; the disease is acute promyelocytic leukemia.