MVMR has been recently employed to disentangle the direct effect for each risk factor not mediated by other correlated risk factors for a range of health outcomes, including a recent study using MVMR to compare the causal roles of lipids and apolipoproteins with coronary artery disease (CAD), which found the effects of LDL-C attenuated in MVMR models accounting for other lipids and lipoproteins, while the direct effect of apolipoprotein B (ApoB) remained, suggesting ApoB as a causal risk factor for CAD [28]. Here, APOB is linked to coronary artery disorder.