HK2 and neoplasm: Indeed, our studies showed a prominent elevation of entire central carbon metabolism in liver tumor tissues of ALDOB KO mice compared to WT mice, including glycolysis, TCA, and PPP [18], which was accompanied by activated Akt and increased expression of HK1 and HK2, suggesting that Aldob deficiency facilitates glucose uptake and metabolic flux through up-regulation of hexokinases to sustain tumor growth.