MYC and neoplasm: More importantly, either Akt inhibition using MK2206 or Akt activation by ectopic expression of Myc-Akt1, but not the Myc-Akt1 phospho-deficient mutant (Myc-Akt1-AA), dramatically diminished Aldob-mediated abovementioned tumor-suppressive effects (Figs 3C and 3D and S2C–S2F).