BRAF and neoplasm: Grouping of lymphocyte interactions by paratope hotspots (GLIPH [15]) revealed two important characteristics of the changed T-cell infiltrate upon BRAF/MEK inhibition: (1) many of the TCRs of expanded T cells cluster together, suggesting that they recognize similar antigens, and (2) several groups co-cluster with TCR sequences with known specificities for shared tumor antigens, i.e., MDAs and CTAs.