EGFR and colorectal cancer: This association had been repeatedly reported in in vitro models (Iorio et al., 2016; Rees et al., 2016) and also found in melanoma cases (Chapman et al., 2011), whilst not in colorectal cancer patients due to feedback activation of ERK-signalling mediated via EGFR (Corcoran et al., 2018; Prahallad et al., 2012).