Oral cancerous and precancerous lesions have shown aberrant epigenetic modifications, including hypermethylation of tumor‐related genes (Castilho et al., 2017; Hema et al., 2017; Lingen et al., 2011) such as E‐cadherin and p16ink4a (Castilho et al., 2017; Hema et al., 2017; Lingen et al., 2011). This evidence concerns the gene CDH1 and neoplasm.