In bladder cancer cell lines B01 and B02, both 2 and 4 μmol/L APX2014 was also more effective in combination with Napa than Napa alone, however the effect in B01 cells was more dramatic and displayed synergy at all doses of Napa (Figure S1B, Isobologram graph in right panel, Table S1 and S2). This evidence concerns the gene NAPA and urinary bladder carcinoma.