In general, STAT3 signalling promotes a tumour microenvironment that enables the tumour to proliferate and spread as well as avoid the immune system; within the tumour, STAT3 regulates pathways involved in cell proliferation, viability, angiogenesis and metastases.59, 68, 69, 70, 71, 72, 73. This evidence concerns the gene STAT3 and neoplasm.