The top 20 genes for the pediatric sepsis turquoise module were mainly enriched in rRNA‐containing ribonucleoprotein complexes exported from the nucleus, NIK/NF‐kappaB signal negative regulation, T‐cell receptor signaling pathway, centromeric peripheral material, mitochondrial inner membrane GO term, CD4 receptor binding, phosphatidylinositol 3‐kinase regulatory subunit binding, etc, enriched in NF‐kappa B signaling pathway, cysteine and methionine metabolism, Th17 cell differentiation, T‐cell receptor signal path and other KEGG pathways. Here, NFKB1 is linked to Sepsis.