The selected hub gene of pediatric sepsis was combined with the markers of cell surface and found 10 core genes (HCK, PRKCD, SIRPA, DOK3, ITGAM, LTB4R, MAPK14, MALT1, NLRC3, LCK) by downloading data and bioinformatics analysis of childhood sepsis. The gene discussed is DOK3; the disease is Sepsis.