In 10 samples from patients with grade 3‐4 ATTR deposits, adipose tissue was recognized, and in 4 of them (2 females, 76 and 75 years, and 2 males, 76 and 80 years), ATTR amyloid appeared with a distribution similar to what is seen in subcutaneous or pericardial fat tissue in patients diagnosed with systemic ATTR amyloidosis (Fig. 6a, b and c). The gene discussed is TTR; the disease is amyloidosis.