Several large dedicated HFpEF studies; Empagliflozin Outcome Trial in Patients with Chronic Heart Failure with Preserved Ejection Fraction (EMPEROR-Preserved) (NCT03057951) and Dapagliflozin Evaluation to Improve the Lives of Patients with Preserved Ejection Fraction Heart Failure (DELIVER) (NCT03619213), are nearing completion and will characterize SGLT2-inhibitor benefit in this cohort. This evidence concerns the gene SLC5A2 and heart failure.