Both data from our lab in whole blood and data from the ArrayExpress database in CD3 T cells (E-GEOD-13887) and B cells (E-GEOD-4588) confirmed the decreased mRNA expression of SCUBE3. Thus, we speculated that the reduced expression of SCUBE3 might contribute to the insufficient activation of the TGF-β signaling pathway promoting the development of SLE. Here, SCUBE3 is linked to systemic lupus erythematosus.