Since GLP-1 receptor agonists are used for the treatment of type 2 diabetes worldwide and for patients with obesity in several countries, our results make us expect that GLP-1 receptor agonists have an additive effect to treat periodontitis in addition to its own glucose-lowering and body weight-lowering effects in patients with type 2 diabetes or obesity. This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.