CCL2 and diabetes mellitus: Dong et al. [69] investigated a monocyte chemoattractant protein-1 (MCP1) polymorphism in an Asian DM cohort, and while they observed a significant association with overall DR risk and proliferative DR, they found no association with severity of DME (mildDME = 207, moderateDME = 173, severeDME = 66).