RYR2 and diabetes mellitus: Alteration in the sensitivity of RyR2 to the Ca2+ activation, oxidation of RyR2 by ROS and/or reactive carbonyl species [43–46], and functional uncoupling of RyR2 from L-type Ca2+ channels on the T-tubule membranes could be partly responsible for the dyssynchronous Ca2+ release from SR in diabetes [47].