It was found that Netrin-1 can effectively reduce brain tissue damage in rats with ischemic stroke, improve the neurological and sensory functions of rats, and also effectively inhibit neuronal cell apoptosis, and Netrin-1 can promote DCC expression and ERK phosphorylation, and EPK signaling pathway may be involved in the antiapoptotic effect of Netrin-1. This evidence concerns the gene DCC and ischemic stroke.