According to the index of infection (Figure 2(b)), a significant level of protection in comparison with the control challenge group (the infection rate, 100%) was achieved in the group that was vaccinated with the tetravalent viral construct (P < 0.01; vaccination efficacy, 80%) expressing the Brucella Omp16, L7/L12, Omp19, and SOD proteins fused to the N-terminal 80 amino acids of NS1. This evidence concerns the gene SOD1 and infection.