PLCE1 and liver dysplastic nodule: For example, diabetic nephropathy (DN) was a major cause of ESRD, and a recent study identified the candidate genes in the progression of DN by microarray dataset analysis [3]; cohorts of hub genes were screened related to disease progression, such as COL6A3, MS4A6A, and PLCE1. Dai et al. performed the gene coexpression network analysis and identified a series of hub genes associated with immune functions in ESRD patients [4].