PDE5A and kidney disorder: The top ten genes with higher values included TMBIM6, REXO1L2P, MAPRE1, LGALSL, DAPP1, CMPK1, BRK1, YWHAQ, TBL1XR1, and PDE5A. Several genes have been shown to be involved in the pathogenesis of nephropathy, such as TMBIM6, BRK1, YWHAQ, and PDE5A; while other genes were fewer reported (REXO1L2P, MAPRE1, LGALSL, DAPP1, CMPK1, and TBL1XR1).