FOXD4 and kidney disorder: By calculating the F score in the XGBoost model [14, 20], we screened cohorts of genes associated with kidney disease progression and the top 20 genes were visualized (Figure 5(c)), such as FZD10, FOXD4, and FAM215A. FZD10 represented the highest score (F score = 20), indicating that it played a major role in disease development.