These results indicate the acute effect of Aβ (1-42) on brain cholesterol accumulation probably through the p53-induced expression of HMGCR enzyme, and treatment with quinovic acid significantly revoked the hypercholesterolemia and mitigated the brain cholesterol levels by deescalating p53 and HMGCR protein levels. Here, HMGCR is linked to familial hypercholesterolemia.