Alzheimer's disease (AD) is the major progressive neurodegenerative disorder associated with brain atrophy and dementia and is typified by various neuropathological features including the presence of extracellular neuritic plaques of amyloid-beta (Aβ) peptides and hyperphosphorylated tau in intraneuronal neurofibrillary tangles (NFTs) [1, 2]. Here, MAPT is linked to Alzheimer disease.