Adding to the list of Nrf2 modulators, two triterpenoids, CDDO (2-cyano-3, 12-dioxooleana-1,9-dien-28-oic acid) ethylamide (CDDO-EA) and CDDO-trifluoroethylamide (CDDO-TFEA), were also described to activate Nrf2/ARE in SOD1G93A mouse model as well as in a cell culture model of ALS [178]. The gene discussed is NFE2L2; the disease is amyotrophic lateral sclerosis.