Over 50 disease-modifying genes have been described in ALS [12]; mutations in chromosome 9 open reading frame 72 (C9orf72) [13, 14], Cu2+/Zn2+ superoxide dismutase type-1 (SOD1) [15–18], TAR DNA-Binding (TARDBP) [19], and fused in sarcoma (FUS) [20, 21] are among the most prevalent ones. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.