In the present study, using a rat model of diabetes, generated by feeding rats with high-fat and high-cholesterol diets and intraperitoneal injection of STZ, or a nerve cell model of high glucose, the results showed that OMT significantly reduced blood glucose and insulin levels, improved cognitive dysfunction and histological changes, inhibited oxidative stress, and suppressed neuronal apoptosis in diabetic rats and SH-SY5Y cells. Here, INS is linked to diabetes mellitus.