The results revealed that a high expression level of CBX3 was apparently related to lymph node metastasis (N+ vs. N0, OR = 2.96, 95% CI 1.42-6.20, P = 0.004); further sensitivity analysis showed that this result was reliable (Supplementary Figure 1). This evidence concerns the gene CBX3 and metastatic malignant neoplasm in the lymph nodes.