Furthermore, imperialine (10 mg/kg for 18 days) prominently blocked the development of non-small-cell lung cancer in the mice model, which involves the downregulation of the levels of inflammatory cytokines, such as IL-1β, IL-6, tumor necrosis factor-α (TNF-α), and the decrease of Ki67 [50]. The gene discussed is TNF; the disease is non-small cell lung carcinoma.