A recent study showed that imperialine (200 ng/mLfor 24 h) notably inhibited the proliferation of human lung adenocarcinoma cell line A549 via downregulating the key regulatory molecules in the nuclear factor-κB (NF-κB) pathway, including phosphoinositide 3-kinase (PI3K) Class III, protein kinase B (Akt), p-Akt, nuclear factor-κB-inducing kinase (NIK), IκB kinase (IKK) α&β, nuclear factor κBα (IκBα), and decreasing the expression of Ki67 (a clinical biomarker for tumor progress evaluation), as well as upregulating the levels of caspase-3. This evidence concerns the gene CASP3 and neoplasm.