CCN2 and injury: Furthermore, peiminine (0.005 g/kg for 28 days) has been demonstrated to exert inhibitory effects on the bleomycin-induced lung injury rat model by reducing the levels of IFN-γ, TGF-β, connective tissue growth factor (CTGF), extracellular signal-regulated kinase (ERK)1/2, NF-κB, and Fas Ligand (FasL) [63].