In contrast, RB1 that was regarded as a tumor suppressor gene [34] in gastrointestinal stromal tumors and was identified as a monotonically increasing gene, while three oncogenes including NFE2L2 [35], ABL1 [36], and LASP1 [37] were identified as monotonically decreasing genes. Here, RB1 is linked to gastrointestinal stromal tumor.