For the top colon cancer MEGs, the consistent tumor suppressor genes included MAP2K4, MAPK10, RUNX3, WNK2 (the four genes were identified by the TSGene 2.0 database), BECN1 [27], FASN [28], NAT1 [29], and NR3C2 [30]. Here, MAPK10 is linked to colonic neoplasm.