For the top colon cancer MEGs, the consistent tumor suppressor genes included MAP2K4, MAPK10, RUNX3, WNK2 (the four genes were identified by the TSGene 2.0 database), BECN1 [27], FASN [28], NAT1 [29], and NR3C2 [30]. The gene discussed is RUNX3; the disease is neoplasm.