In addition, hepatic expression of LXRα, SREBP-1c, and their target genes, such as acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and stearoyl-CoA desaturase (SCD), has been found to be significantly upregulated in liver biopsies from nonalcoholic fatty liver disease (NAFLD) patients [19]. This evidence concerns the gene NR1H3 and metabolic dysfunction-associated steatotic liver disease.