They also occur at very low frequencies in diffuse large B-cell lymphoma (DLBCL), marginal zone lymphoma (MZL), and chronic lymphocytic leukemia (CLL), but allow differentiation to other lymphomas such as IgM multiple myeloma (MM), which virtually never shows MYD88 mutations [64]. The gene discussed is MYD88; the disease is B-cell chronic lymphocytic leukemia.