By multivariable analysis, the covariates most associated with ICU admission included chemotherapy intent (non-curative vs. curative), PLT < 50 × 109/L, acute leukemia, albumin below normal limits (< 37 g/L), LDH above normal limits (> 250 U/L), and advanced directive discussion in hospital pre-ICU admission (yes versus no) (Table 2). This evidence concerns the gene ALB and acute leukemia.