Accordingly, the aim of this study was to evaluate the influence of genetic polymorphisms (GSTM1, GSTT1, XRCC1 –rs25487-, ERCC1 –rs11615, rs3212986, ERCC2 –rs13181-, XRCC3 –rs861539-, OGG1 –rs1052133- and Alpha-1-antitrypsin (AAT) mainly located in the BER and NER DNA repair pathways on survival and toxicity among never-smoker LC patients. Here, ERCC1 is linked to laryngotracheoesophageal cleft.