B. monnieri plant extract/bacoside A enhances calcium/calmodulin-dependent protein kinase type II subunit alpha (CaMK2A) and activates CaMK2A phosphorylation (pCaMK2A) in glioblastoma cells, and pCaMK2A triggers high calcium release from the endoplasmic reticulum, causing macropinocytotic and membrane hydrostatic stress-induced tumor cell death. This evidence concerns the gene CAMK2A and neoplasm.