In our previous study, PPE was found to present cytotoxic properties and cooperate with temozolomide (TMZ), synergistically enhancing its growth-inhibiting activity against the glioblastoma U87MG cell line through the reduced activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)14. The gene discussed is NFKB1; the disease is glioblastoma.