Although, immunofluorescence staining of SIRT1 showed inhibition in nuclear SIRT1 expression in ATM inhibited DLBCL cells compared with ATM-WT DLBCL cells, this difference was not significantly different from that observed in ATM deficient normal fibroblasts when compared to WT-ATM cells (Supplementary Fig. S1E). Here, ATM is linked to diffuse large B-cell lymphoma.