Interestingly, we observed a decrease in utilization of TCA substrates (Fig. 4B) and a trend towards increased utilization of substrates such as, citric acid, aconitic acid glutamic acid, glutamine and tryptamine in DLBCL cell lines expressing shATM (Fig. 4C) and CKO-ATM (Fig. 4D) compared to wild type ATM-DLBCL cell lines. The gene discussed is ATM; the disease is diffuse large B-cell lymphoma.