To investigate whether the deletion of RORα in macrophages might play a role in advanced NAFLD, WT and MKO mice were fed with the choline-deficient, L-amino acid-defined (CDAA) diet supplemented with sucrose and 2% cholesterol for 8 weeks, leading to a pronounced hepatic steatosis, inflammation and fibrosis, but dissociated from obesity and IR allowing the analysis of liver-centric responses9. Here, RORA is linked to obesity due to melanocortin 4 receptor deficiency.