First, plasma palmitoylcarnitine (as well as other conjugated acylcarnitines) was reduced in the NLRP3 deficient mice on both HFD and control diet compared to WT mice, and interestingly, increased levels of acylcarnitines have been observed in several metabolic and inflammatory conditions like T2DM, obesity and CVD, potentially related to mitochondrial dysfunction48. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.