Moreover, we have recently showed that NLRP3 deficient mice on high fat diet (HFD) were protected from adverse myocardial remodeling, and the absence of NLRP3 inflammasome components was shown to suppress obesity-induced hepatic steatosis and systemic inflammation and seemed also to have beneficial effects on glucose metabolism22. Here, NLRP3 is linked to obesity due to melanocortin 4 receptor deficiency.