The present study is a follow-up on our previous article, Sokolova et al.22, where we have shown that NLRP3 deficiency in mice on HFD has a beneficial effect on obesity-induced myocardial remodeling and dysfunction with attenuated infiltration of Mac-2 positive cells, insulin sensitivity, systemic inflammation (decreased levels of IL-18 and tumor necrosis factor), and liver steatosis. The gene discussed is INS; the disease is Obesity.