NLRP3 and cardiovascular disorder: The NLRP3 inflammasome may represent a link between overnutrition, metabolic stress, inflammation, and development of metabolic and cardiovascular diseases, but the molecular mechanisms for these interactions are not fully elucidated35,36. Herein we show several effects of NLRP3 deficiency on control diet, and in particular HFD associated metabolic changes in plasma, but also in the liver and within the myocardium.