POLQ and cancer: Twelve genes harboring pDGVs in the WCM-UC cohort were listed as causally implicated in cancer in the COSMIC Cancer Gene Census15 (https://cancer.sanger.ac.uk/census), and six genes (BRCA2, FANCA, XPA, POLQ, PTPN13, and RECQL4) were previously reported to harbor germline mutations in several cancer types (Supplementary Data 6).